Synthesis, Spectroscopy, Antibacterial and Anti-inflammatory Studies of Homo and Hetero Bimetallic Complexes with Bifunctional (O, S) Ligand

Mafia Noreen; Shabbir Hussain; Muhammad Shahid; Shazma Massey; Amina Asghar; Khurram Shahzad Munawar

doi:10.53560/PPASB(62-2)1075

Authors

Mafia Noreen Department of Chemistry, Lahore Garrison University, DHA Phase VI, Lahore, Pakistan
Shabbir Hussain Institute of Chemistry, Khwaja Fareed University of Engineering and Information Technology, Rahim Yar Khan 64200, Pakistan
Muhammad Shahid Department of Chemistry and Biochemistry, University of Agriculture, Faisalabad, Pakistan
Shazma Massey Department of Chemistry, Forman Christian College (A Chartered University), Lahore 54600, Pakistan
Amina Asghar Department of Chemistry, Division of Science and Technology, University of Education, Lahore 54770, Pakistan
Khurram Shahzad Munawar Department of Chemistry, University of Mianwali, 42200, Pakistan

DOI:

https://doi.org/10.53560/PPASB(62-2)1075

Keywords:

Homobimetallic (Sn, Sn), Heterobimetallic (Sn, Cd/Zn), Spectroscopy, TGA, Antibacterial, Anti-inflammatory

Abstract

Current studies were performed to synthesize homo- (Sn & Sn) and heteronuclear (Sn & Cd/Zn) complexes (1-7) of sarcosine dithiocarbamate and investigate their antibacterial and anti-inflammatory potential. Homobimetallic products, i.e., Ph₂(Cl)SnSSCLSn(Cl)Me₂ (1), Ph₂(Cl)SnSSCLSn(Cl)Me₃ (2), Ph₂(Cl)SnSSCLSnBu₃ (3) were produced by a reaction of sarcosine (HLH), CS₂and Ph₂SnCl₂ and then with Me₂SnCl₂, Me₃SnCl and Bu₃SnCl, respectively. Ph₃SnSSCLSn(Cl)Bu₂ (4) and Ph₃SnSSCLSnMe₃ (5) were produced by reacting HLH with KOH, CS₂ and Ph₃SnCl firstly and then with Bu₂SnCl₂and Me₃SnCl, respectively. The heteronuclear products, i.e., (Ph₃SnSSCL)₂Cd (6) and (Ph₃SnSSCL)₂Zn (7) were formed by reaction between HLH, KOH, CS₂ and Ph₃SnCl followed by treatment with CdCl₂or ZnCl₂, respectively. Elemental analysis data was agreed well with the molecular composition of the products. Fourier transform infrared (FTIR) spectroscopy have shown the bidentate binding of carboxylate and dithiocarbamate donor sites of ligand. Proton nuclear magnetic resonance (¹H NMR) spectroscopy of 3 displayed the expected signals of ligand portion and organotin(IV) moieties. TGA data of product 7 verified its heterobimetallic (2Sn, ZnO) composition. All the products except 4 and 6 exhibited significant antimicrobial activities as compared to free ligand. The highest anti-inflammatory potential was displayed by product 3.

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