Hepatic and Renal Histopathological Effects of Local Fruit Juices containing Sodium Benzoate as Preservative
Histopathological effects of locally packed fruit juices on liver & kidney of mice
DOI:
https://doi.org/10.53560/PPASB(59-3)719Keywords:
Fruit juices, food preservative, sodium benzoate, necrosis, tumorogenesis.Abstract
Packed fruit juices are commonly consumed on daily basis around the globe which usually contains sodium benzoate as food preservative to enhance their shelf life and its amount may vary from defined food standards among brands. This mammalian model based research was designed to investigate the impact of locally packed fruit juices’ regular intake on consumers. For this purpose, albino mice (Mus musculus) were acclimatized in laboratory environment for ten days and then categorized in control and two experimental groups. The selected local brands were Murree brewery lemon malt and Shezan mango juice and their 0.1ml prepared dose was given to experimental groups I and II, respectively, whereas; control group was treated with equivalent amount of distilled water. The obtained histopathological results emphasized that regular intake of sodium benzoate having fruit juices may cause severe damage to hepatic and renal tissues, usually in the form of necrosis, vascular congestion sometimes dilation and other cellular alterations i.e., in glomeruli and bile duct. Moreover, it may result in onset of tumorogenesis. The conclusion of this study is local food authorities should ensure the addition of a defined amount of sodium benzoate as juice preservative in locally packed juices to provide healthy products to consumers.
References
B. Prakash, A. Kedia, P. K. Mishra, A. K. Dwivedy and N. K. Dubey. Assessment of chemically characterized Rosmarinus officinalis L. essential oil and its major compounds as plant based preservative in food system based on their efficacy against foodborne moulds and aflatoxin secretion and as antioxidant. International Journal of Food Science & Technology, 50(8): 1792-1798 (2015).
B. S. Lennerz, S. B. Vafai, N. F. Delaney, C. B. Clish, A. A. Deik, K. A. Pierce and V. K. Mootha. Effects of sodium benzoate, a widely used food preservative, on glucose homeostasis and metabolic profiles in humans. Molecular Genetics and Metabolism, 114(1): 73-79 (2015).
A. Yadav, A. Kumar, M. Das & A. Tripathi. Sodium benzoate, a food preservative, affects the functional and activation status of splenocytes at non cytotoxic dose. Food and Chemical Toxicology, 88: 40-47(2016). H. C. Han. Twisted blood vessels: symptoms, etiology and biomechanical mechanisms. Journal of vascular research, 49(3): 185-197 (2012).
F. Khodaei, H. Kholghipour, M. Hosseinzadeh & M. Rashedinia. Effect of sodium benzoate on liver and kidney lipid peroxidation and antioxidant enzymes in mice. Journal of Reports in Pharmaceutical Sciences, 8(2): 217-19 (2019).
D. Matheoud, T. Cannon, A. Voisin, A. M. Penttinen, L. Ramet, A. M. Fahmy & M. Desjardins. Intestinal infection triggers Parkinson’s disease-like symptoms in Pink1−/− mice. Nature, 571 (7766): 565-569 (2019).
I. S. Khan, K. B. Dar, S. A. Ganie & M. N. Ali. Toxicological impact of sodium benzoate on inflammatory cytokines, oxidative stress and biochemical markers in male Wistar rats. Drug and Chemical Toxicology, 45(3): 1345-1354 (2022).
M. Hasson, E. M. Majhwol, H. J. N. Almuoswi. Evaluation of some kidney functions of rates treated with sodium benzoate. Annals of the Romanian Society for Cell Biology, 4859–4866 (2021).
A. Javed & J. I. Qazi. Testosterone propionate promotes angiogenesis and nerve regeneration in extensor digitorrum longus muscle grafts. Sindh University Research Journal-SURJ (Science Series), 50(01): 59-64 (2018).
H. Erfan, S. M. Yousef, K. A. R. I. M. A. El-Sayed & A. Z. Mohamed. Assessment of the effect of concomitant use of sodium benzoate and fructose on the liver structure and function in young albino rats. The Medical Journal of Cairo University, 89(June): 761-767 (2021).
M. Sen. Food chemistry: role of additives, preservatives, and adulteration. Food Chemistry: The Role of Additives, Preservatives and Adulteration, 1-42 (2021).
World Health Organization. Understanding the Codex Alimentarius. Food and Agriculture Organization 247: 1-19 (2018).
H. Chen, M.M. Brashears, and Q. Zhong. Sodium benzoate and sodium bisulfate as preservatives in apple juice and alternative sanitizers for washing cherry tomatoes. International Journal of Food Microbiology 109697 (2022).
T. Alawiyah, and I. Yuwindry. Analysis of sodium benzoate levels in drink samples carbonized with brand X. Proceedings of the First National Seminar Universitas Sari Mulia 1-6 (2020).
M. Aslam, S. Hamid, S. Khalid, H. Kamran, and S. Azhar. Determination of preservative sodium benzoate in selected samples of fruit juices and squashes. Asian Journal of Allied Health Sciences 27-32 (2020).
K. Zeghib, and D.A. Boutlelis. Food additive (sodium benzoate)-induced damage on renal function and glomerular cells in rats; modulating effect of aqueous extract of Atriplex halimus L. Iranian Journal of Pharmaceutical Research 20(1), 296 (2021).
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